Traditionally medicine has had difficulty in identifying people at risk of developing a disease or in the very early stages of disease. A comprehensive innovative approach designed to detect early signs of potential disease would allow early stage intervention before serious consequences occur.
The emergence of low-cost Omic analysis makes it possible to now analyse an individual at the molecular level affordably. Integrating individual Omic data will improve and maintain health, detect disease before it is serious, select the right treatment at the right time and provide objective feedback on therapeutic efficacy. Compiling this longitudinal data from populations of healthy and eventually those affected by disease has the added benefit of establishing a large data set to identify accurate biomarkers, novel drug targets and when integrated with health outcome data, predict best practices for a population of individuals. Such technology has the potential for establishing new intellectual property and additional opportunities to commercialize findings.
Molecular You combines comprehensive analysis of molecular markers with big data analytics to profile health at a level that has never before been possible. Individual genomes will be sequenced and analyzed to identify genetic risk factors for disease and other health markers. Levels of a comprehensive panel of plasma proteins (proteome) and metabolites (metabolome) will be quantified. Microbial species (microbiome) present in the gut and other places on the body will be monitored and correlated with the state of health of individuals. Critical parameters such as heart rate, blood pressure, and oxygenation and behavioural patterns like physical activity, diet and sleep will also be monitored. All data generated will be analyzed using integrated computational biology approaches to objectively characterize health status and transitions from health to disease correlated with various Omic metrics. Participants will receive regular consultation with a healthcare professional to interpret data and discuss potential options to act on to maintain a healthy state.
Individualized data will be presented to participants using a totally new graphical interface to produce a dashboard for health that highlights actionable possibilities and tracks the progress to health.
The plan is to grow the Molecular You database and strengthen the value of the science by adding findings from similar studies within the PMI Data Commons, a privacy-by-design PHEMI Central database.
Profiles of the first 11 Pathfinders have been completed and shared with them. In addition, Molecular You has made ‘MY Profile’ available to selected physicians. The Molecular You platform will empower individuals to take a proactive approach to managing their health in close consultation with their health professional. Molecular You has numerous focused disease characterization studies underway with a variety of clinician and investigator partners.
Molecular You will gather the high-level comparison data needed to identify disease risk or presence in healthy individuals and patients — from molecular changes to organ functioning. In addition to the health maintenance benefits to participants, the large database created from this study will be a powerful source of information to develop biomarkers indicating health status and early indications of transition to disease. Such data will be the basis of new intellectual property and proprietary opportunities to create industries focused on maintaining wellness and the early personalized prevention of diseases before they become dangerous.
With this data, personalized medicine will become increasingly effective, accessible and mainstream and improve the safety, efficiency and effectiveness of the healthcare system, potentially reduce per capita costs, and dramatically improve patient and provider healthcare experiences.
Initiative leads: Pieter Cullis, David Huntsman, Bruce McManus, Jim Russell, Martin Dawes and Rob Fraser
Change in clinical practice: Molecular Precision for Performance and Health
Company Website: Molecular You